Sorafenib tosylate, known by its CAS number 475207-59-1, is a powerful multikinase inhibitor primarily used in the treatment of advanced cancers such as hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), and differentiated thyroid carcinoma (DTC). As a highly active pharmaceutical ingredient (API), Sorafenib tosylate plays a vital role in targeted cancer therapy due to its dual-action mechanism of inhibiting tumor cell proliferation and angiogenesis. At Yikang Chemical (https://yikanghuagong.com/), we are committed to supplying top-grade Sorafenib tosylate with strict quality control and global regulatory compliance.
What Is Sorafenib Tosylate?
Sorafenib tosylate is the tosylate salt form of Sorafenib, a small molecule that blocks multiple intracellular and cell surface kinases, including RAF kinases, VEGFR, PDGFR, and c-KIT. This broad kinase inhibition allows it to interfere with tumor growth and vascularization, making it a key component in cancer therapeutics.
Chemical Details:
- CAS Registry Number: 475207-59-1
- Molecular Formula: C21H16ClF3N4O3 × C7H8O3S
- Therapeutic Class: Anticancer agent, Kinase inhibitor
- Common Brand Name: Nexavar
Key Medical Applications
Sorafenib tosylate is FDA-approved and widely used in clinical oncology to treat:
- Hepatocellular Carcinoma (HCC): First-line treatment for unresectable liver cancer.
- Renal Cell Carcinoma (RCC): Effective in advanced kidney cancer.
- Differentiated Thyroid Carcinoma (DTC): Applied when radioactive iodine therapy fails.
Its wide-ranging efficacy in targeting tumor signaling pathways makes it a backbone in targeted molecular therapy.
Mechanism of Action
Sorafenib tosylate exerts its anticancer effects by:
- Inhibiting RAF/MEK/ERK pathway, disrupting tumor cell division.
- Blocking VEGFR and PDGFR, reducing tumor blood supply.
- Suppressing receptor tyrosine kinases involved in tumor progression.
This multifaceted approach makes Sorafenib tosylate a valuable tool in precision oncology.
Yikang Chemical: Your Trusted Source for Sorafenib Tosylate
As a reliable API manufacturer and exporter, Yikang Chemical ensures:
- High Purity Sorafenib Tosylate suitable for pharmaceutical formulation.
- Strict GMP-compliant manufacturing environment.
- Robust QC systems including HPLC, NMR, and MS for batch verification.
- Global Supply Chain Support ensuring safe and timely delivery.
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To help clients discover us easily, we support global search with the following relevant terms:
- Sorafenib tosylate supplier
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Let’s Partner for a Healthier Future
Yikang Chemical welcomes collaborations with pharmaceutical companies, research institutions, and distributors worldwide. For more details or inquiries about Sorafenib tosylate CAS 475207-59-1, visit us at: https://yikanghuagong.com/
Together, let’s advance the future of targeted cancer therapy.
