Shandong Yikang Pharmaceutical Co., Ltd. primarily engages in the research, development, manufacturing, and sale of active pharmaceutical ingredients (APIs). It also provides comprehensive CDMO services for various APIs and pharmaceutical intermediates. The company was established in 2019 with a registered capital of RMB 3 million. Covering an area of over 200,000 square meters, the entire project is divided into three distinct phases. The first phase occupies 50,000 square meters and construction commenced in February 2020. Currently, the main structures of this phase have been completed, with full completion expected by June 2023 and operations commencing in July 2023. Yikang’s present API products include febuxostat, rosuvastatin calcium, lenvatinib mesylate, sunitinib malate, sorafenib tosylate, and erlotinib hydrochloride.
The company operates two production workshops covering a combined floor area of 6,400 square meters. These facilities consist of five separate production lines, each equipped with independent D-level clean areas. The workshops feature extensive equipment, including 69 reactors ranging in capacity from 50 L to 3000 L, 27 centrifuges (models LB450 to LB800), 29 drying machines of varying capacities and types, and 13 mixing and crushing devices of different specifications. This setup enables the company to effectively handle diverse CDMO projects involving a wide array of raw materials and pharmaceutical intermediates.
All reactors are equipped with TCU automated temperature regulation systems, DCS distributed control systems, SIS safety instrumented systems, and various safety interlocking mechanisms. These advanced setups allow the execution of multiple reaction types, such as metal coupling, amide condensation, heterogeneous hydrogenation, asymmetric (transfer) hydrogenation, as well as reactions catalyzed by acids (including Lewis acids) and bases. Additionally, the facilities support complex and hazardous synthetic reactions, including hydrogenation, nitrification, sulfonation, oxidation, chlorination, fluorination, polymerization, diazotization, peroxidation, azotization, alkylation, amination, phosgene reactions, and photogasification.
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