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Sunitinib malate

CAS code:341031-54-7

Indications:
Gastrointestinal stromal tumor (GIST) and advanced renal cell carcinoma.

Pharmacology:
A small molecule inhibitor of multiple receptor tyrosine kinases (RTKs), some of which are involved in tumor growth, pathological angiogenesis, and metastasis.

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Tadalafil

CAS:171596-29-5 Indications: Erectile dysfunction and pulmonary hypertension Pharmacology: It is a selective reversible inhibitor of guanosine cyclophosphate (cGMP)-specific phosphodiesterase 5 (PDE5).When sexual stimulation leads to the local release of nitric oxide, PDE5 is inhibited by tadalafil, which increases the level of cGMP in the cavernous body of the penis, which leads to relaxation of smooth muscles and blood flowing into the penis tissue to produce an erection, such as asexual stimulation.

Tadalafil intermediate

CAS code: 171752-68-4 English name: (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE

TAK-788

Chinese Name: TAK788
English Name: TAK-788
Purity: 99.0%
Product Category: Intermediate


Background Information:
On January 15, 2020, the Center for Drug Evaluation (CDE) of the China National Medical Products Administration (NMPA) announced that TAK-788, developed by Takeda, has received implicit clinical trial approval in China.
TAK-788 is a next-generation, potent, and selective small molecule tyrosine kinase inhibitor (TKI), specifically developed to treat non-small cell lung cancer (NSCLC) patients with EGFR exon 20 insertion mutations.


Keywords:
TAK788; TAK-788; AP 32788

TATM

Chinese Name: 三氟甘露糖
English Name: TATM
CAS Number: 92051-23-5
Purity: 99.0%
Product Category: Intermediate


Chinese Synonyms:

  • 甘露糖三氟磺酸酯

  • 1,3,4,6-四乙酰-2-三氟甲烷磺酰-β-D-吡喃甘露糖

  • 1,3,4,6-O-四乙酰基-2-O-三氟甲磺酰基-β-D-吡喃甘露糖

  • 四-邻-乙酰基-2-三氟甲烷-黄酰基吡喃甘露糖

English Synonyms:

  • BETA-D-Mannopyranose 1,3,4,6-tetraacetate 2-triflate

  • 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose

  • 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethylsulphonyl-β-D-mannopyranose

  • Mannose triflate


Molecular Formula: C₁₅H₁₉F₃O₁₂S
Molecular Weight: 480.36

EINECS Number: Not available
Structure File: Available as 92051-23-5.mol


Keywords:
92051-23-5; TATM; Mannose triflate; 三氟甘露糖; 甘露糖三氟磺酸酯