Rosuvastatin calcium, identified by CAS number 147098-20-2, is a calcium salt form of Rosuvastatin, a synthetic statin class drug used extensively to treat hyperlipidemia and prevent cardiovascular disease. As one of the most potent HMG-CoA reductase inhibitors on the market, Rosuvastatin calcium is a critical active pharmaceutical ingredient (API) in the management of elevated cholesterol and related atherosclerotic conditions. At Yikang Chemical (https://yikanghuagong.com/), we specialize in providing GMP-grade Rosuvastatin calcium for formulation, generic drug development, and international pharmaceutical markets.
Pharmacological Overview
Rosuvastatin calcium exerts its lipid-lowering effect by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol biosynthesis. This leads to:
- Increased LDL receptor expression in the liver
- Enhanced clearance of LDL-C (low-density lipoprotein cholesterol)
- Modest increase in HDL-C (high-density lipoprotein cholesterol)
- Reduction in total cholesterol, ApoB, and triglycerides
These multi-targeted benefits contribute to reducing the risk of myocardial infarction, stroke, and revascularization procedures.
Chemical and Physical Properties
- Molecular Formula: C22H27FN3O6S·Ca
- Molecular Weight: ~1001.14 g/mol (hydrated salt)
- CAS Registry Number: 147098-20-2
- Synonyms: Rosuvastatin calcium salt, Rosuvastatin Ca
- Appearance: White to off-white powder
- Solubility: Freely soluble in methanol and ethanol, practically insoluble in water
Therapeutic Applications
Rosuvastatin calcium is approved for monotherapy and combination use in the following conditions:
- Primary Hyperlipidemia and Mixed Dyslipidemia
- Homozygous Familial Hypercholesterolemia (HoFH)
- Primary Prevention of Cardiovascular Disease in High-Risk Populations
- Atherosclerotic Cardiovascular Disease (ASCVD) Risk Reduction
- Adjunct Therapy for Pediatric and Adolescent Hyperlipidemia (in selected countries)
It is marketed under brand names such as Crestor, and available as generics globally.
Yikang Chemical’s Rosuvastatin Calcium API
We offer Rosuvastatin calcium with:
- GMP-compliant manufacturing and full traceability
- Purity levels >99.0% verified by HPLC
- Comprehensive documentation: COA, MSDS, DMF-ready support
- Particle size customization and micronized grades
- Packaging tailored for commercial or R&D scale
Advanced Quality Assurance
All batches undergo rigorous QC using:
- High-Performance Liquid Chromatography (HPLC)
- Infrared Spectroscopy (FTIR)
- Mass Spectrometry (LC-MS)
- Chiral Purity and Residual Solvent Profiling
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Contact Yikang Chemical
Looking to source a reliable Rosuvastatin calcium API supplier with global experience and strong regulatory support? Reach out to Yikang Chemical.
➡ Visit: https://yikanghuagong.com/ for technical specs, samples, and quotations.
Yikang Chemical — Empowering global heart health with quality-driven APIs.
