Product Name: Nafamostat Mesilate

CAS No.: 82956-11-4
Purity: ≥99.0%
Category: API (Active Pharmaceutical Ingredient)
Shelf Life: 1 year
Storage: Store in a cool, dry place away from light
Molecular Formula: C₁₉H₁₇N₅O₂·(CH₄O₃S)₂
Molecular Weight: 539.58

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Description

Nafamostat mesilate is a synthetic serine protease inhibitor. It exhibits potent inhibition against trypsin, plasmin, kallikrein, and components of the complement system (C1r, C1s), and has shown efficacy in treating acute pancreatitis by reducing pancreatic enzyme activity and mortality rates in animal models.

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Application & Indications

• Acute pancreatitis

• Postoperative pancreatitis or pancreatitis after pancreatic duct imaging

• Disseminated intravascular coagulation (DIC)

• Prevention of coagulation during extracorporeal circulation

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Market Background

First approved in Japan in 1986 by Japan Tobacco, Nafamostat has become a widely used treatment for acute pancreatitis. Its ability to selectively inhibit activated enzymes involved in inflammation and coagulation makes it a key drug in emergency and critical care.

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Form: Lyophilized powder for injection (10mg per vial)
Regulatory Classification: Chemical Drug Class 3.1

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Keywords: 82956-11-4; Nafamostat mesilate; Nafamostat; Serine protease inhibitor; Acute pancreatitis treatment