Active Pharmaceutical Ingredient

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Allyl Trifluoroacetate

English Name: Allyl Trifluoroacetate
Alias: Allyl 2,2,2-Trifluoroacetate; 2,2,2-Trifluoroacetic Acid Allyl Ester; Prop-2-Enyl 2,2,2-Trifluoroethanoate
Product Name: Allyl Trifluoroacetate
Purity Specification: 98.0%
Product Category: Intermediate
Grade: Pharmaceutical Grade

Molecular Structure: CAS Registry Number: 383-67-5, Allyl Trifluoroacetate
Molecular Formula: C5H5F3O2
Molecular Weight: 154.09
CAS Registry Number: 383-67-5
EINECS Registry Number: 206-853-7

SMILES: C(C=C)OC(C(F)(F)F)=O
InChI: 1S/C5H5F3O2/c1-2-3-10-4(9)5(6,7)8/h2H,1,3H2
InChIKey: XIVPVSIDXBTZLM-UHFFFAOYSA-N

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Ammonium trifluoroacetate

English Name: Ammonium trifluoroacetate
Alias: Ammonium trifluoroacetate salt
Product Name: Ammonium trifluoroacetate
Purity Specification: 98.0%
Product Category: Intermediate
Grade: Pharmaceutical Grade

Molecular Structure: CAS Registry Number: 3336-58-1, Ammonium trifluoroacetate
Molecular Formula: C2H4F3NO2
Molecular Weight: 131.05
CAS Registry Number: 3336-58-1
EINECS Registry Number: 222-072-4

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Amprolium hydrochloride

CAS code: 137-88-2

Indications:
Coccidiosis.

Pharmacology:
Amprolium competitively inhibits the uptake of thiamine by coccidia. Within cells, thiamine is converted to thiamine pyrophosphate, a coenzyme involved in the oxidative decarboxylation of α-keto acids during carbohydrate metabolism, specifically as a cofactor for the α-keto acid dehydrogenase complex. Since amprolium lacks the hydroxyethyl group of thiamine, it cannot be phosphorylated to the active coenzyme form, thereby blocking key metabolic reactions. This disruption of carbohydrate metabolism inhibits the development of coccidia.

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Avanafil

CAS code: 330784-47-9

Appearance:
Off-white to white powder.

Pharmacology:
Avanafil is a highly selective oral phosphodiesterase type 5 (PDE5) inhibitor. Phase I, II, and III clinical trials have shown that, compared with other PDE5 inhibitors, avanafil has the advantages of rapid onset of action, shorter duration, fewer adverse effects, and favorable clinical efficacy and safety profile.

Application:
Avanafil is a PDE5 inhibitor used for the treatment of erectile dysfunction.

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Baclofen

English Name: Baclofen
Chinese Name: 巴氯芬
CAS Number: 1134-47-0
Purity Specification: 98.0%
Product Category: Intermediate
Grade: Pharmaceutical Grade
Alias: beta-(Aminomethyl)-4-chlorobenzenepropanoic acid; Lioresal

Molecular Formula: C10H12ClNO2
Molecular Weight: 213.66 g/mol
CAS Registry Number: 1134-47-0
EINECS Registry Number: 214-486-9

Structure:

  • CAS Registry Number: 1134-47-0, Baclofen, 4-Amino-3-(4-chlorophenyl)-butyric acid

Keywords: 1134-47-0; Baclofen

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Baricitinib

Product Name: Baricitinib
CAS No.: 1187594-09-7
Purity: ≥99.0%
Category: API (Active Pharmaceutical Ingredient)
Shelf Life: 1 year
Storage: Room temperature, protect from light

Molecular Formula: C16H17N7O2S
Molecular Weight: 371.42

Indication:
Baricitinib is used for the treatment of moderate to severe rheumatoid arthritis (RA).

Mechanism of Action:
A selective JAK1 and JAK2 inhibitor, with IC50 values of 5.9 nM and 5.7 nM respectively. It shows ~70-fold and ~10-fold selectivity over JAK3 and Tyk2, with no inhibitory activity on c-Met or Chk2.

Approval Status:
Originally developed by Incyte and co-developed with Eli Lilly.

  • EMA approved (Feb 14, 2017) under the brand name Olumiant.

  • NDA submitted to FDA in January 2016.

Keywords: 1187594-09-7; Baricitinib; Olumiant; JAK inhibitor; rheumatoid arthritis treatment

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