Active Pharmaceutical Ingredient

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Crisaborole

Chinese Name: 克立硼罗
English Name: Crisaborole
CAS: 906673-24-3
Purity Specification: 99.0%
Product Category: API

IUPAC Name: 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile
Alias: AN 2728

Product Name:
克立硼罗;4-[(1,3-二氢-1-羟基-2,1-苯并氧杂硼杂环戊烷-5-基)氧基]苯甲腈

Molecular Formula: C₁₄H₁₀BNO₃
Molecular Weight: 251.05
CAS Registration Number: 906673-24-3

Keywords: 906673-24-3; Crisaborole; 克立硼罗; AN 2728

Dabrafenib mesylate

English name: Dabrafenib mesylate
Alias: GSK 2118436 methanesulfonate salt; GSK 2118436B; N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide methanesulfonate
Product name: Dabrafenib mesylate

Molecular structure: CAS Registry number: 1195768-06-9, Dabrafenib mesylate

Molecular formula: C23H20F3N5O2S2.CH4O3S
Molecular weight: 615.67
CAS Registry number: 1195768-06-9

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Dapoxetine hydrochloride

CAS code|: 129938-20-1

Chemical Name:
Dapoxetine hydrochloride is chemically known as (S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-phenylpropanamine hydrochloride.

Pharmacology:
Dapoxetine hydrochloride shares similar pharmacological activity with other selective serotonin reuptake inhibitors (SSRIs). Initially developed as an antidepressant, dapoxetine differs from traditional SSRIs in its pharmacokinetics—exhibiting rapid oral absorption, short half-life, and fast elimination. These properties make it suitable for on-demand use in the treatment of premature ejaculation (PE).

Clinical Use:
Dapoxetine hydrochloride is a short-acting oral SSRI used to treat premature ejaculation in men. Developed by Eli Lilly, it was first launched in Europe in 2009 under the brand name Priligy.

Physical Properties:
Dapoxetine hydrochloride is a white to off-white powder. It is readily soluble in methanol and ethanol, slightly soluble in 1,2-dichloroethane, and almost insoluble in water. As a BCS Class II compound, its poor solubility is a key factor contributing to variability in clinical efficacy. Dapoxetine hydrochloride exists in multiple polymorphic forms, which can exhibit significant differences in solubility and may undergo phase transformation.

Adverse Effects:
During treatment, dapoxetine tablets may cause side effects such as headache, dizziness, nausea, vomiting, fatigue, and diarrhea. These adverse effects are typically mild and transient, posing no serious threat to patients and usually resolving quickly.

Dasatinib monohydrate

Chinese Name: 达沙替尼一水合物
English Name: Dasatinib monohydrate
CAS Number: 863127-77-9
Purity: 99.0%
Product Category: API (Active Pharmaceutical Ingredient)


Other Names:

  • Chinese: 达沙替尼;一水达沙替尼

  • English Synonym:
    N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate

IUPAC Name:
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate


Molecular Formula: C₂₂H₂₆ClN₇O₂S·H₂O
Molecular Weight: 506.02

CAS Registry Number: 863127-77-9

Keywords: 达沙替尼;863127-77-9;达沙替尼一水合物;一水达沙替尼;Dasatinib monohydrate

Dicyclanil

English Name: Dicyclanil
Chinese Name: 地昔尼尔
CAS Number: 112636-83-6
Purity Specification: 98.0%
Product Category: Active Pharmaceutical Ingredient (API)
Grade: Pharmaceutical Grade
Alias: 4,6-Diamino-2-(cyclopropylamino)-5-pyrimidinecarbonitrile

Molecular Formula: C8H10N6
Molecular Weight: 190.21 g/mol
CAS Registry Number: 112636-83-6

Structure:

  • CAS Registry Number: 112636-83-6, Dicyclanil, 4,6-Diamino-2-(cyclopropylamino)-5-pyrimidinecarbonitrile

Keywords: 112636-83-6; Dicyclanil

Diethylphosphorodithioate

English Name: Diethylphosphorodithioate
Alias: O,O-Diethyl dithiophosphate; Phosphorodithioic acid O,O'-diethyl ester
Product Name: Diethylphosphorodithioate; O,O-Diethyl dithiophosphate
Purity Specification: 98.0%
Product Category: Intermediate
Grade: Pharmaceutical Grade

Molecular Structure: CAS Registry Number: 298-06-6, Diethylphosphorodithioate, O,O-Diethyl dithiophosphate
Molecular Formula: C4H11O2PS2
Molecular Weight: 186.22
CAS Registry Number: 298-06-6
EINECS Registry Number: 206-055-9

Keywords: 298-06-6; Diethylphosphorodithioate; O,O-Diethyl dithiophosphate