Avanafil, with the CAS number 330784-47-9, is a highly selective phosphodiesterase type 5 (PDE5) inhibitor designed for the treatment of erectile dysfunction (ED). As a second-generation oral PDE5 inhibitor, Avanafil offers significant advantages in onset speed, target selectivity, and patient tolerability. Marketed globally under brand names such as Stendra and Spedra, Avanafil has become a prominent option in urological medicine. At Yikang Chemical (https://yikanghuagong.com/), we provide pharmaceutical-grade Avanafil for formulation, generics development, and clinical research.
Chemical and Pharmacological Profile
- IUPAC Name: (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
- Molecular Formula: C23H26ClN7O3
- Molecular Weight: 483.95 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Slightly soluble in DMSO and methanol; practically insoluble in water
Mechanism of Action
Avanafil inhibits the PDE5 enzyme, preventing the degradation of cyclic guanosine monophosphate (cGMP) in corpus cavernosum smooth muscle. By increasing cGMP levels, Avanafil promotes vasodilation, enhancing blood flow and enabling erection upon sexual stimulation. Its high selectivity reduces cross-reaction with PDE1 and PDE6, minimizing side effects like visual disturbances or systemic vasodilation.
Clinical Advantages
- Fast Onset: Action begins within 15–30 minutes after oral administration
- Short Duration: Ideal for on-demand use with minimal residual effects
- High Selectivity: Reduced off-target side effects compared to sildenafil or vardenafil
- Effective in Comorbid Conditions: Can be used by patients with diabetes, hypertension, or post-prostatectomy
Formulations and Global Use
Avanafil is available in 50 mg, 100 mg, and 200 mg film-coated tablets. It is approved by FDA (USA), EMA (Europe), and several national regulatory agencies.
Yikang Chemical: High-Quality Avanafil API Supplier
At Yikang Chemical, we ensure:
- GMP-compliant manufacturing environment
- Purity >99.0% verified via HPLC
- Full analytical documentation: COA, MSDS, NMR, residual solvent profiles
- Support for DMF filing and global regulatory audits
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Get in Touch
For inquiries regarding Avanafil API supply, sample requests, or technical specifications, please contact us:
Yikang Chemical — Advancing men’s health through precision pharmaceutical manufacturing.
