Amprolium hydrochloride, with CAS number 137-88-2, is the hydrochloride salt of Amprolium — a well-established coccidiostat widely used in the prevention and treatment of coccidiosis in poultry and livestock. As a competitive antagonist of thiamine (vitamin B1), Amprolium hydrochloride disrupts the thiamine uptake of Eimeria parasites, effectively halting their growth and reproduction. At Yikang Chemical (https://yikanghuagong.com/), we provide high-purity Amprolium hydrochloride with consistent quality and GMP-aligned production standards.
Chemical Identity & Properties
- Chemical Name: Amprolium hydrochloride
- CAS Number: 137-88-2
- Molecular Formula: C14H19Cl2N3•HCl
- Molecular Weight: 336.19 g/mol
- Appearance: White or almost white crystalline powder
- Solubility: Soluble in water; practically insoluble in organic solvents
Mechanism of Action
Amprolium hydrochloride acts as a thiamine analog that selectively blocks thiamine transporters in Eimeria spp., the protozoan parasites responsible for coccidiosis. This inhibition leads to metabolic failure in the parasites without harming the host animal, making it a safe and effective coccidiostat for animal health.
Veterinary Applications
Amprolium hydrochloride is widely used as an active pharmaceutical ingredient in:
- Poultry farming (broilers and layers): Control and prevention of intestinal coccidiosis caused by E. tenella, E. acervulina, E. maxima
- Ruminants (calves, goats, sheep): Management of bovine coccidiosis
- Combination therapies: Often formulated with sulfonamides or other ionophores for broad-spectrum action
Available in oral powders, water-soluble concentrates, premix additives, and medicated feeds.
Advantages of Amprolium Hydrochloride from Yikang Chemical
- High assay and batch consistency
- Complies with veterinary pharmacopeia (USP, EP, BP)
- Stable under various storage conditions
- Suitable for feed and water medication formats
- Low toxicity with excellent safety profile
Quality Control Measures
We ensure each batch of Amprolium hydrochloride undergoes:
- HPLC Purity Testing
- Residual Solvent Analysis
- Heavy Metal and Microbial Limit Testing
- Particle Size Adjustment (on request)
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Work with Yikang Chemical
If you’re sourcing Amprolium hydrochloride for veterinary pharmaceutical formulations or feed premixes, Yikang Chemical is your ideal partner.
➡ Visit our website: https://yikanghuagong.com/ for quotes, technical documentation, and regulatory support.
Yikang Chemical — Delivering dependable APIs for global veterinary care.
